University of Florida Research Foundation, Incorporated

Georgia Tech Research Corporation

Fishing Physics, LLC

Bartlett, Brian P.

Wallace Gregory Sawyer

Thomas Ettor Angelini

Tapomoy Bhattacharjee

David Lawrence Burris

Steven Craig Ghivizzani

Jennifer Vail

Brent S Sumerlin

Kyle D Schulze

Kyle Gene Rowe

Brandon Alexander Krick

Nicole Lee McCook

Scott S Perry

Derek L Hood

C Parker Gibbs

Alexander Rudy

John C Ziegert

Tanmay P Lele

Carl David Crane

Brian P Bartlett

Alberto Fernandez-Nieves

Samantha M Marquez

Ya-Wen Chang

Curtis Taylor

Joshua Muse

Meghan Hughes

Glyn Daniel Palmer

Ben Peter Boesl

Angela Athena Pitenis

Christopher S O'Bryan

Christopher P Junk

Steven Raymond Lustig

Gregory Scott Blackman

Nicolas Argibay

Mark David Wetzel

Tony Lavaun Schmitz

Daniel John Dickrell, Iii

Richard D Clark, Iii

Jeffrey John Ewin

Ben Peter Boesi

Alexander Rejender Webber

Jeffrey Alan Bardt

Gerald R Bourne

Juan Manuel Uruena

Ryan M Nixon

Eric O McGhee

Samantha Lauren Marshall

Alexander McGhee

Kylie E Van Meter

Juan Manuel Urueña

Michael Dougherty

Christian Jobin

Padraic P Levings

Jack E Famiglietti

William R Niederhauser

Ryan A Smolchek

Cameron Morley

Wallace C Sawyer

Mike Norton

Gregory John Toupalik

Kylie Van Meter

Juan Manuel URUEÑA

Angela A Pitenis

A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. Cells may be placed in the three-dimensional cell growth medium according to any shape or geometry, and may remain in place within the three-dimensional cell growth medium.

Growth media for three-dimensional cell culture

Embodiments of the present disclosure provide for lubricious structures (also referred to simply as 'structure'), methods of making lubricious structures, methods of using lubricious structures, and the like.

Lubricious structures, methods of making them, and methods of use

Various examples are provided for modular prosthetic devices and their use. In one example, a device includes a chassis assembly including a joint portion; and an interchangeable module that can be removably attached to the chassis assembly. The interchangeable modules can be configured for use in a wide variety of applications. The interchangeable modules can be quickly exchanged for different activities.

Modular prosthetics devices

Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or 'stress yield' material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.

Valve incorporating temporary phase change material

Disclosed herein is a bioreactor system that allows perfusive flow through a porous support medium enabling 3D growth of biological samples. In some embodiments, the system comprises a sample well filled with a three-dimensional (3D) cell growth medium. The system can further comprises a liquid medium reservoir fluidly connected to the sample well by a first filter material. The system can further comprises a medium collection chamber fluidly connected to the sample well by a second filter material. The system can further comprise an absorbant material that creates an osmotic pressure gradient to produce perfusive flow. In some embodiments, osmotic pressure draws fluid from the liquid medium reservoir, through the first filter material, into the sample well where it permeates the three-dimensional cell growth medium, through the second filter material, and finally into the medium collection chamber.

Perfusion bioreactor driven by osmotic pressure gradients

A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

High speed 3D printing system for wound and tissue replacement

An organic microgel system as support material for 3D printing of soft materials such as silicone and methods for manufacturing and using the organic microgel system are disclosed. In some embodiments, the organic microgel system comprises a plurality of microgel particles formed by blending a di-block copolymer and a tri-block copolymer in an organic solvent. The organic microgel system may allow high precision 3D printing of silicone objects with complex shapes.

Organic microgel system with di&#x2014;and tri-block blends of herschel-bulkley fluid for 3D printing of sacrificial support structures

Disclosed herein is a bioreactor system that allows active perfusive flow through a porous support medium enabling 3D growth of biological samples. In some embodiments, the system comprises a sample well filled with a three-dimensional (3D) cell growth medium. The system can further comprise a liquid medium reservoir fluidly connected to the sample well by a first filter material. The system can further comprises a medium collection chamber fluidly connected to the sample well by a second filter material. In some embodiments, application of negative gage pressure to the medium collection chamber or positive pressure to the liquid medium reservoir draws fluid from the liquid medium reservoir, through the first filter material, into the sample well where it permeates the three-dimensional cell growth medium, through the second filter material, and finally into the medium collection chamber.

Perfusion enabled bioreactors

Described herein are methods and apparatus for constructing tissue replacements, such as bone replacements that may be used to repair damaged or missing segments of bone, such as may occur in wound repair or as a repair of a congenital anomaly. These methods involve a three-dimensional (3D) cell growth medium made from a yield stress material that allows cells and structures to be easily deposited and positioned.

Fabrication of autologous bone

Disclosed herein is an integrated assay system that can be used, for example, to monitor and screen cells in 3D culture. This system involves a 3D cell growth medium made from a yield stress material that allows cells to be deposited, e.g. by 3D printing, samples to be taken, and the extracellular environment manipulated.

3D micro fabrication and screening

Organic microgel system for 3D printing of silicone structures

Growing community of inventors

Gainesville, FL, United States of America

Wallace Gregory Sawyer