Wacker Chemie Ag

Consortium Fur Elektrochemische Industrie Gmbh

Consortium F{umlaut Over (u)}r Elektrochemische Industrie Gmbh

Walfred Leinfelder

Tobias Dassler

Guenter Wich

Gunter Wich

Keith Backman

Peter Heinrich

Günter Wich

The invention relates to a method for producing L-cysteine and its derivatives L-cystine and thiazolidine by fermenting a cysteine-producing microorganism strain in a fermentation medium. The invention is characterized in that L-methionine, L-isoleucine, or L-threonine in respective concentrations ranging from 0.1 to 10 g/L are added to the fermentation medium in the main culture.

Method for the fermentative production of L-cysteine and derivatives of said amino acid

A tryptophan producing strain of microorganism is selected from,and Corynebacteria and is tryptophan feedback resistant and serine feedback resistant. The serine feedback resistance is by a mutation in a serA allele, where the mutated serA allele codes for a protein which has a K,value for serine between 0.1 mM and 50 mM. The tryptophan feedback resistance is by a trpE allele which codes for a protein which has a K,value for tryptophan between 0.1 mM and 20 mM. A process for preparing this microorganism and a process for using this microorganism are disclosed.

Microorganisms for the production of tryptophan and process for the preparation thereof

Microorganisms and processes for the fermentative preparation of L-cysteine, L-cystine, N-acetylserine or thiazolidine derivatives. The microorganism strain which is suitable for the fermentative preparation of L-cysteine, L-cystine, N-acetylserine and/or thiazolidine derivatives, overexpresses at least one gene which encodes a protein which is directly suitable for secreting antibiotics, or other substances which are toxic for the microorganism, out of the cell.

Microorganisms and processes for the fermentative preparation of

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M{umlaut over (u)}nchen, Germany

Walfred Leinfelder