Transmedics, Inc.

The United States Government As Represented by the Department of Veterans Affairs

Other

Transmedic, Inc.

Waleed H Hassanein

Tamer I Khayal

Richard Bringham

Ahmed Elbetanony

Giovanni Cecere

Stanley Kyi

John Sullivan

Robert Havener

Robert Fishman

Scott W Newell

Paul Lezberg

Mark Anderson

Ihab Abdel Fattah

Dennis Sousa

Anas Abdelazim

Hossam Algamil

Burt Ochs

Vincent Lambert, Ii

Greg Ritchie

Doug Harriott

Matthew De Remer

Paul Murray

Michael Van Driel

Ronald Taylor

Ron Taylor

Shukri F Khuri

Michael D Crittenden

Robert Havner

Dmitri Menn

Jonathan M Rourke

Ronald L Taylor, Jr

Jeff Barnes

Vladimir Birjinuik

Tom Bishop

Larry Goff

Thomas H Bishop

Elizabeth Hansen Bulger

David M Carpenter

John Rourke

Hesham Saleh

Jon C Trachtenberg

Elizabeth Hansen

Lawrence Goff

Vladimir Birjiniuk

Elizabeth (Hansen) Bulger

Hoss Algamil

Vincent Lambert Ii

Jon Trachtenberg

The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Systems and methods for ex vivo lung care

The disclosure provides for electrode systems and perfusion systems that may be configured to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems may maintain the heart in a beating state at, or near, normal physiological conditions; circulate oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure, and/or flow rate. These systems may include a pair of electrodes that may be placed epicardially on the right atrium and/or left ventricle of the explanted heart, and/or an electrode placed in the aortic blood path.

Systems for monitoring and applying electrical currents in an organ perfusion system

The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.

Aortic cannula for ex vivo organ care system

The invention provides, in various embodiments, a method comprising placing an ex-vivo heart in a chamber of an organ care system; connecting the ex-vivo heart to a perfusion fluid circuit of the organ care system; starting a pump configured to provide, via the perfusion fluid circuit, a perfusion fluid to the ex-vivo heart; synchronizing at least one maximum output of the pump with an r-wave of the ex-vivo heart; testing the ex-vivo heart or the organ care system; adjusting a setting of the organ care system in response to a result of the testing; and after adjusting the setting of the organ care system in response to the result of the testing, re-testing the ex-vivo heart or the organ care system.

Systems and methods for ex-vivo organ care

The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

Ex vivo organ care system

Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.

The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.

An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.

Organ care solution for ex-vivo machine perfusion of donor lungs

The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.

Systems, methods, compositions and solutions for perfusing an organ

The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near physiologic conditions. In certain embodiments, the disclosure relates to testing properties of an ex-vivo heart or an organ care system, adjusting a property of the organ care system in response to certain results of the testing, and re-testing the ex-vivo heart or the organ care system. In certain embodiments, the disclosure relates to synchronizing at least one cycle of a pumping of a perfusion fluid with a state of the ex-vivo heart.

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the:) The overall perfusion status of an isolated heart and) The metabolic status of an isolated heart and) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

An organ care system including a blood product heater that includes a heater inlet, a channel, and a heater outlet, wherein the heater inlet includes an inside cross-sectional area and an inside cross-sectional shape configured to flow a blood product into the blood product heater, wherein the heater outlet comprises an inside cross-sectional area and an inside cross-sectional shape configured to flow the blood product out of the blood product heater, and wherein the channel extends between the heater inlet and the heater outlet and is formed between a first flow channel plate and a second flow channel plate; and a first heater thermally coupled to the first flow channel plate configured to heat the first flow channel plate; and a pump configured to circulate a heated blood product to an organ being preserved.

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North Andover, MA, United States of America

Waleed H Hassanein