Sagami Chemical Research Center

Kaken Pharmaceutical Company, Ltd.

Japan Finechem Company, Inc.

Sagami Chemical Research Institute

Wakako Yokota

Kenji Hirai

Tetsu Yamakawa

Atsushi Uchida

Tomoyuki Yano

Hidenori Aihara

In a process for producing 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylate (3) by a reaction of 2-alkoxymethylenefluoroacylacetate (1) and hydrazine (2), the reaction is conducted in the presence of a base and water, to produce 1-substituted-3-fluoroalkylpyrazole-4-carboxylate (3) with high selectivity and yield. This novel process enables to produce 1-substituted-3-fluoroalkylpyrazole-4-carboxylate (3), which is useful as an intermediate for pharmaceuticals and agrochemicals, with high selectivity and yield by simple and safe operations.

Process for producing 1-substituted-3-fluoroalkylpyrazole-4-carboxylate

Disclosed are pyrazole-1-carboxylate derivatives of the general formula (1),  According to this invention, there can be industrially advantageously produced 3-aryloxypyrazole-1-carboxamide derivatives that does not cause chemical damage on crops but exhibits excellent herbicidal activity against weeds that impair the growth of such crops.

Pyrazole-1-carboxylate derivatives, process for the production thereof and process for the production of pyrazole derivatives

Growing community of inventors

Kanagawa, Japan

Wakako Yokota