The Texas A&M University System

The Scripps Research Institute

International Aids Vaccine Initiative

Waithaka Mwangi

Luc Berghman

Surya Waghela

Dennis R Burton

Ian A Wilson

Vaughn V Smider

Devin Sok

Michael Criscitiello

The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab')2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.

Rapid elicitation of broadly neutralizing antibodies to HIV Env

The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.

Mosaic chimeric viral vaccine particle

Growing community of inventors

College Station, TX, United States of America

Waithaka Mwangi