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University of California

Wai-Nang P Lee

Alain L Fymat

Michael D Harpen

Moses A Greenfield

Jeffry A Siegel

This invention comprises a method and apparatus for measuring both the absolute levels and variations of radioactivity emitted following administration of suitable radioisotopes during a test period by selected organs. Miniaturized radiation detectors for measuring two different types of radiation, such as gamma rays and photons, for example, are modified by the addition of mutual overlap coincidence units, scalers, single channel analyzers and time-gates. The individual detector units are appropriately arranged to form a probe or collar in either a strip or a checkerboard configuration, extending around the neck to study the thyroid gland or other gland organ to be analyzed. The associated electronic architecture is appropriately designed in either simplex or multiplex circuit patterns. Measurements are performed according to an established, preprogrammed time schedule that is reflective of the functional processes of the organ undergoing testing, and which separately determine the background radiation and that emanating from the organ or gland being examined. The data is recorded and processed by a dedicated microcomputer means. With a properly chosen radiopharmaceutical, the measurements provide specific data useful for clinical evaluation of the physiological functions and morphological features of the organ.

Coincidence counting emission tomographic probe: method and apparatus

Clinical method for evaulating thyrometabolic function by determination of clinically important thyroxine concentrations and thyroxine binding protein capacities in plasma. The method employs a competitive binding technique for determining free thyroxine concentration and thyroxine binding capacity for plasma having a known total thyroxine concentration.

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Van Nuys, CA, United States of America

Wai-Nang P Lee