Agency for Science, Technology and Research

National University Hospital

National University Hospital (singapore) Pte. Ltd.

Wai Kiong Ng

Reginald Tan

Sie Huey Lee

Desmond Heng

Jeanette Teo

Leonard Chia

Shou-Cang Shen

The present disclosure provides dry powder antibiotic compositions that are effective in the treatment of bacterial infections and associated conditions. Moreover, the present disclosure provides dry powder antibiotic compositions for the treatment of bacterial infections, by multi-drug resistant bacteria, resulting in the subsequent reduction in the prevalent rates of drug resistance.

Antibiotic compositions for treating bacterial infections

A dry powder formulation comprising a combination of at least a first pharmaceutically active quinolone and a second pharmaceutically active quinolone.

Dry powder formulation

The present invention encompasses formulations and methods for producing solid dispersions comprising mesoporous materials with poorly aqueous soluble active ingredients. The active ingredient is formed in the amorphous state and entrapped in the nanosized pores of the mesoporous excipients using a co-spray drying process. The pore walls of mesoporous channels stabilize the amorphous form of active ingredient against re-crystallization. The amorphous active ingredient entrapped in mesoporous channels exhibits good stability during extended storage under stress test conditions and possesses significantly enhanced dissolution rates.

Mesoporous material excipients for poorly aqueous soluble ingredients

Growing community of inventors

Singapore, Singapore

Wai Kiong Ng