Cedars-sinai Medical Center

Wafa Tawackoli

Hyun W Bae

Dan Gazit

Gadi Pelled

Zulma Gazit

Debiao Li

Edward M Schwarz

Dmitriy Sheyn

Qi Liu

Described herein are methods and compositions using PTH and mesenchymal stem cells (MSCs) for treatment of osteoporosis, bone fractures, and related conditions. Administration of both PTH and MSCs leads to increased homing of MSCs to sites of vertebral bone and rib fracture. The described methods and compositions provide therapeutic approaches that rely, in-part, on stem cell capacity for regeneration and repair. The potential for enhanced bone formation and fracture repair may allow for both preventative and palliative treatments in osteoporotic patients, with combined PTH+MSC therapy producing bone regeneration capacity that is significantly superior to either treatment alone.

Method for non surgical repair of vertebral compression fractures

The present invention teaches novel methods of diagnosing and prognosing conditions associated with tissue degeneration and/or pain, including intervertebral disc degeneration, discogenic pain, osteoarthritis, rheumatoid arthritis, and articular cartilage injury. Using the inventive noninvasive imaging methods, the diagnosis and prognosis of back pain and related conditions can be quickly and accurately determined by detecting one or more biomarkers disclosed herein.

Imaging biomarkers for the diagnosis and prognosis of back pain and related conditions

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Beverly Hills, CA, United States of America

Wafa Tawackoli