Pharmacia & Upjohn Company

The Upjohn Co.

Wade J Adams

Donn G Wishka

Joel Morris

Mikhail Fedor Gordeev

Upinder Singh

Jackson Boling Hester, Jr

Carole Scott

Jeffrey Charles Stevens

Janice M Friis

The present invention describes difluororthioacetamide oxazolidinones of formula I:R is &#x2014;CH&#x2014; or &#x2014;CHCH&#x2014;; Rand Rare independently &#x2014;H or &#x2014;F; X is &#x2014;CH&#x2014;; Y is &#x2014;SO&#x2014;, &#x2014;SO&#x2014;, or &#x2014;SONR&#x2014;; and Ris &#x2014;H or &#x2014;Calkyl. These compounds are useful to treat infectives diseases caused by gram-positive and gram-negative bacteria.

Difluorothioacetamides of oxazolidinones as antibacterial agents

The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R.sub.4 is selected from the group consisting of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, --NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and

Thioalkyl alpha substituted pyrimidine compounds

A temperature controlled sample carrier, usable in liquid chromatography apparatus, includes a rotating sample rack having a circumferential array of upward facing sample holes adjacent its periphery for receiving sample vials and orbiting same sequentially past a sampling station. The rack is a solid cylindrical block of heat conducting material which forms a massive heat sink. An insulative cup receives the sample block and rotates therewith. A temperature control device carries a controlled temperature fluid in heat conductive contact with the central portion of the sample block and is overlaid by an insulative cover device which rotates with the block. An insulative cover ring is fixed with respect to the sampling station, overlies the array of sample holes in the block, and extends between the peripheral wall of the cup and the cover device. A circumferentially narrow opening in the cover ring permits access by a sampling device at the sampling station to the upper ends of sequentially presented sample vials rotating therepast with the sample block.

Temperature controlled sample carrier

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Kalamazoo, MI, United States of America

Wade J Adams