Amersham Biosciences Ab

W Travis Johnson

Peiming Zhang

George W Hawkins

Charles K Brush

Abhijit Mazumder

Mark W McGarry

Chang-Gong Liu

Michael Gaskin

Norman Gery Fuller

Methods and devices for detecting nucleic acid and protein targets on hydrogel microarrays are disclosed. Fluorophores are incorporated into the targets and detected. A linear correlation between target concentration and signal amplitude is maintained through the elimination of active enzyme amplification.

Hydrogel-based microarray signal amplification methods and devices therefor

The present invention provides a method and an improved apparatus for removing gas bubbles from a reaction chamber comprising a flexible layer removably affixed to a substrate layer having a multiplicity of oligonucleotide binding sites disposed thereon, in which biological reactions are performed. The invention specifically relates to methods and apparatus for removing gas bubbles from a reaction chamber wherein target molecules contained in a sample fluid are reacted with probe molecules immobilized on a substrate having an array of oligonucleotide binding sites. The arrays are covered with a flexible, gas permeable layer that permits mixing of the sample fluid on the biochip and removal of gas bubbles from the fluid by use of a means for facilitating diffusion of gas bubbles across the flexible, gas permeable layer.

Method and apparatus for performing biological reactions on a substrate surface

This invention provides efficient methods for producing a covalent linkage having improved chemical stability between an amine-containing biomolecule and a solid support or hydrogel surface containing an aldehyde moiety.

Schiff base reductant co-dispense process

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Chandler, AZ, United States of America

W Travis Johnson