Wake Forest University

The Uab Research Foundation

W Todd Lowther

Jeffrey Daniel Schmitt

Daniel Yohannes

Steven J Kridel

Ross P Holmes

Herman H Odens

Provided herein are compounds of Formula (I), Formula (II), and Formula (III), and compositions comprising the same, as well as methods of use thereof for controlling or inhibiting the formation of calcium oxalate kidney stones, inhibiting the production of glyoxylate and/or oxalate, and/or inhibiting hydroxyproline dehydrogenase (HYPDH).

HYPDH inhibitors and methods of use for the treatment of kidney stones

Active compounds useful for inhibiting fatty acid synthase in a subject in need thereof are described. The active compounds are, in general, a 5-mercapto-1H-Indazole-4,7-dione or an analog thereof. The compounds are useful for treating subjects afflicted with, cancer, obesity, diabetes, a viral infection, a bacterial infection, a fungal infection, or a protozoal infection.

Methods of treating cancer and other disorders

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Pfafftown, NC, United States of America

W Todd Lowther