Becton Dickinson and Company Limited

W Shannon Dillmore

Rajendra R Bhat

Douglas Byron Sherman

Joseph Thomas

Adam Craig Curry

Helen Hsieh

Steven Keith

J Bruce Pitner

Alexander George Lastovich

Robert E Pearson

James L Schram

Christian Sandmann

Helen V Hsieh

Kristin Weidemaier

Adam C Curry

Andrea Liebmann-Vinson

W William Stewart

Kirstin Weidemaier

Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

Assays using surface-enhanced raman spectroscopy (SERS)-active particles

Nanoparticles comprising surface-enhanced Raman scattering (SERS) reporter molecules of the formula A-Y and methods of their use are disclosed, wherein A is: wherein Xis CRor N; and Y is selected from the group consisting of: 

Near-infrared dyes as surface enhanced raman scattering reporters

Nanoparticles comprising surface-enhanced Raman scattering (SERS) reporter molecules of the formula A-Y and methods of their use are disclosed, wherein A is selected from the group consisting of: wherein Xis CRor N; and Y is selected from the group consisting of: 

The current invention relates to sensing elements and devices comprising at least one amphipathic lipid-binding protein or fatty acid binding protein, wherein the binding proteins are associated with a luminescent reporter group. The binding proteins and luminescent reporter groups are encapsulated within a hydrogel matrix that comprises at least one co-monomer, wherein the co-monomer is present at a concentration that decreases or inhibits micelle formation of the amphipathic lipid. Binding of the amphipathic lipid or fatty acid to the appropriate binding protein can produce at least one detectable change in the property of the luminescent reporter group.

Biosensor device for sensing amphipathic analytes

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Raleigh, NC, United States of America

W Shannon Dillmore