Boston University

Microbiotix, Inc.

W Ranjith Premasiri

Donald T Moir

Larry Ziegler

The present invention provides a nanostructured substrate for SERS. A substrate of the invention comprises a surface featuring substantially monodisperse-sized metal nanoparticles disposed thereon. Preferably, the substrate surface provides for SERS and spectra therefrom. For example, a nanostructured substrate of the invention can be used to reproducibly and reliably detect or identify pathogens, molecules or combinations thereof. In one embodiment, a nanostructured substrate of the invention comprises a surface featuring metal nanoparticles substantially aggregated in clusters thereon. Exemplary metal nanoparticles disposed on the substrate surface can be silver, copper, gold or combinations thereof. Metal nanoparticles disposed on a substrate surface can also be substantially spheroidal comprising diameters in a range from about 40 to 120 nm. The invention also provides methods for syntheses and uses of a nanostructured substrate comprising a surface featuring substantially monodisperse-sized metal nanoparticles.

Nanostructured substrate for surface enhanced raman scattering

A Raman scattering spectrographic analyzer wherein a microscope objective is adapted to view single bio-specimens on a substrate having monodispersed-sized metal particles. A defined wavelength of radiation is applied through the microscope and returning radiation resulting from Raman scattering by bio-specimens is applied to a spectrometer operative to provide a signal corresponding to the wavelength components in said Raman scattered or shifted radiation. The spread spectrum of the Raman shift is analyzed for identification of a bio-specimen.

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Weymouth, MA, United States of America

W Ranjith Premasiri