The University of North Carolina at Chapel Hill

Florida State University Research Foundation, Inc.

Duke University

Auburn University

Other

Albert Einstein College of Medicine

The University of Nc at Ch

W David Wilson

David W Boykin

Richard Ray Tidwell

Christine C Dykstra

John R Perfect

Chad F Stephens

Arvind Kumar

James E Hall

Reto Brun

Mohamed A Ismail

Kenny V Brock

Karl Werbovetz

David A Stringfellow

Arvid Kumar

Reem K Arafa

Maurice Daniel Givens

Byron L Blagburn

Iris Francesconi

Bijan P Das

Laixing Hu

Jaroslaw Spychala

Maged M Henary

Ulrich G Steidl

Chad E Stephens

Iléana Anthony-Debré

Gregory Poon

Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.

Carbocyanines for G-quadruplex DNA stabilization and telomerase inhibition

Disclosed herein are inhibitors of PU.1. The inhibitors are useful for treating disorders associated with abnormal PU.1 levels and function.

PU.1 inhibitors

Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A, Y, and Zis N; Aris phenylene; and Aris a nitrogen-containing aromatic group. An exemplary compound of Formula (III) is: 

Substituted pyridines as antiparasitic AZA teraryl compounds

Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds. The presently disclosed compounds can include those of the formulas:  Land Lare selected from the group consisting of: 

Linear dicationic terphenyls and their aza analogues as antiparasitic agents

Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR. An exemplary compound of Formula (IIe) is: Methods for combating microbial infections, such as parasiticspecies, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.

Teraryl components as antiparasitic agents

Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to(T.b.r.) and. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.

Fused ring dicationic anti-protozoan agents and their prodrugs

A satellite distributed high-speed Internet 'Hotspot' enables wireless and hardwired, satellite distributed Internet access aboard a transit vehicle such as a train for anyone with a PC or other web-ready device (wireless ready or cabled) and a valid credit card or prepaid coupon. Internet access is obtained via a ground-based satellite dish, which is operatively coupled to a wireless access point located along the transit route such as a railroad track. The wireless access point is in communication with a wireless transceiver unit located on the transit vehicle, and the Internet signal is distributed to users on the transit vehicle via a router using wired or wireless connections. A plurality of wireless access points can be located along the transit route, thereby allowing the transit vehicle to maintain the Internet connection while traveling along the transit route.

Satellite distributed high speed internet access

The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R, R, Rand Rare each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; Ris H, alkyl or aryl; Ris H, alkyl, aryl, or NRR, in which Rand Rare each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR, in which Ris H or alkyl, and to the use of such compounds.

Synthesis and antimicrobial activity of novel dicationic 'reversed amidines'

Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus, orcomparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of ainfection.

Bichalcophenes and their prodrugs as antiprotozoal agents

A method for treating a microbial infection, including an infection from a protozoan pathogen, such asand, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.

Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection

The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula in which R, R, Rand Rare each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; Ris H, alkyl or aryl; Ris H, alkyl, aryl, or NRR, in which Rand Rare each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR, in which Ris H or alkyl, and to the use of such compounds.

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)&#x2013;(VI) as recited throughout the application.

Growing community of inventors

Atlanta, GA, United States of America

W David Wilson