Rohm and Haas Company

W David Weir

Edward E Kilbourn

Martha H Wolfersberger

Ernest D Weiler

Michael C Seidel

Acetyl- and carbalkoxythioureidobenzophenones having a substituted amine adjacent to the thioureido radical are disclosed as having anthelmintic and antifungal activity.

Acetyl- and carbalkoxythioureidobenzophenones

This invention relates to novel anthelmintic compounds containing an arylene or divalent heterocyclic ring whose free valences are satisfied by

Phosphonoureide and phosphonothioureide anthelmintics

Phosphoramidates and salts and salt complexes useful as anthelmintics are disclosed. The products are prepared by treating an aminobenzene with an appropriately substituted isothiocyanatoate.

Method and composition for treating helminths containing

2-Imino substituted isothioureidobenzene products useful as anthelmintics and fungicides are disclosed. The products may be prepared by several different methods including treating a 2-iminothioureidobenzene with a base and either an organic halide, a diester of sulfuric acid or a diester of sulfurous acid or treating a 2-aminoisothioureidobenzene with an appropriately substituted aldehyde.

2-Imino substituted isothioureidobenzene

Substituted phosphoramidates of the general formula: ##STR1## and their pharmaceutically acceptable metal salts and metal salt complexes, compositions containing them, and methods of employing them as anthelmintics are disclosed.

Bis-phosphoramidates

This invention relates to novel anthelmintic compounds containing an arylene or divalent heterocyclic ring whose free valences are satisfied by 1. a disubstituted phosphoryl ureido or thioureido group and 2. an amino group or a substituted amido or thioamido group, To compositions containing them, and to methods of using them for the treatment of intestinal parasites in mammals and birds.

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Levittown, PA, United States of America

W David Weir