Pharmacopeia Inc.

Pharmacopeia Drug Discovery, Inc.

Vu Van Ma

Vinh D Tran

Ruiyan Liu

Photocleavable and acid cleavable linkers for combinatorial chemistry

A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R,is &mdash;NO,or &mdash;CHO; R,is &mdash;OCH,, &mdash;CHO or &mdash;H; R,is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n&equals;1 or 3.

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Westlake Vlg, CA, United States of America

Vu Van Ma