Universite Claude Bernard – Lyon1

Nh Theraguix

Centre National De La Recherche Gantifote—cnrs—

Vu Long Tran

Olivier Tillement

François Lux

Fabien Rossetti

Vivek Thakare

The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: &#x2014;the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0&#x2264;A&#x2264;6, &#x2014;the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0&#x2264;B&#x2264;5, &#x2014;the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0&#x3c;C&#x2264;8. The invention also relates to the obtained ultrasmall silica nanoparticles.

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Ho Chi Minh, Vietnam

Vu Long Tran