Bantam Pharmaceutical, LLC

Aduro Biotech Inc.

Vu Linh Ly

Stephane Ciblat

M Arshad Siddiqui

Alan B Cooper

Lea Constantineau-Forget

Chantal Grand-Maitre

Gerald W Shipps

Nicolas Bruneau-Latour

Martin Dery

Xiangyu Guo

Sanjay Srivastava

Chudi Obioma Ndubaku

Yeeman K Ramtohul

Franck Raeppel

Leonard Sung

George Edwin Katibah

Mariam Zaky

Laura Gillard

Hossein Ismaili

Tucker Curran Roberts

Taras Rybak

Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts and N-oxides thereof, wherein X, X, Z, Z, the ring system denoted by 'a', R, A, L, A, L, L, Q, L, R, A, L, A, L, R, L, and Rare as described herein. In certain embodiments, compounds disclosed herein disrupt the eIF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.

Substituted pyrazole and pyrrole compounds and methods for using them for inhibition of initiation of translation and treatment of diseases and disorders relating thereto

The present invention relates to pyrazolopyrimidinone compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating autoimmune, inflammatory, and neurodegenerative diseases by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Pyrazolopyrimidinone compounds and uses thereof

Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure (I) and pharmaceutically acceptable salts and/V-oxides thereof, wherein X, X, Z, Z, the ring system denoted by 'a', R, A, L, A, L, L, Q, L, R, A, L, A, L, R, L, and Rare as described herein. In certain embodiments, compounds disclosed herein disrupt the eIF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism. 

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Montreal, Canada

Vu Linh Ly