Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Boehringer Ingelheim Gmbh

Boehringer Ingelheim (canada) Ltd.

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Other

Celamerck Gmbh & Co. Kg

Boehringer Ingelheim Gesellschaft MIT Beschrankter Haftung

Volkhard Austel

Joachim Heider

Helmut Pieper

Johannes M Weisenberger

Frank Himmelsbach

Willi Diederen

Norbert Hauel

Manfred Reiffen

Wolfgang Eberlein

Brian Guth

Gunter Linz

Christian Lillie

Guenter Linz

Walter Kobinger

Wolfgang Eisert

Thomas Mueller

Thomas Muller

Eberhard Kutter

Rudolf Kadatz

Jacobus C Van Meel

Jurgen Dammgen

Pierre Louis Beaulieu

James Gillard

George Kukolj

Gulrez Fazal

Klaus Reinhold Noll

Elke Seewaldt-Becker

F Himmelsbach

Walter Haarmann

Walter Haarman

Gerd Krueger

Thomas M Uller

G Unter Linz

Josef Nickl

Johannes Keck

Gerd Kruger

Jacques Van Meel

Andreas Bomhard

Joachim Kahling

Gunther Linz

A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH, NMeR, NHR; ORor 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said heterocycle being optionally substituted with from 1 to 4 substituents; A is N, CORor CR, wherein Ris H, halogen, or (C) alkyl and Ris H or (Calkyl), with the proviso that X and A are not both N; Ris H, halogen, (Calkyl) or OR, wherein Ris H or (Calkyl); The compounds of the invention may be used as inhibitors of hepatitis C virus replication. The invention further provides a method for treating or preventing hepatitis C virus infection.

Viral polymerase inhibitors

The present invention relates to carboxylic acid derivatives of the general formula ##STR1## in which R.sub.a to R.sub.c, A, B, D, E and X.sub.1 to X.sub.3 are as defined in claim 1, their tautomers, their stereoisomers including their mixtures, and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases, which have useful pharmacological properties, preferably aggregation-inhibiting inhibiting actions, medicaments containing these compounds, their use and processes for their preparation.

Carboxylic acid derivatives, medicaments comprising these compounds,

Substituted phenylamindines, medicaments containing these compounds and

The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.

Biphenyl derivatives, pharmaceutical compositions containing these

The present invention relates to piperazine derivatives of the general formula ##STR1## in which R.sub.a, Y.sub.1 to Y.sub.3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.

Piperazine derivatives, medicaments comprising these compounds, their

The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.

Cyclic urea derivatives, pharmaceutical compositions containing these

The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.

The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.

Cyclic dericatives, pharmaceutical compositions containing these

5-Membered heterocyclic compounds, of which the following compounds are exemplary:

5-membered heterocycles, medicaments containing these compounds, their

Piperazine derivatives useful in the treatment or prevention of inflammation, bone degradation, thrombosis and tumor metastasis. Exemplary species are:

Piperazine derivatives, pharmaceutical compositions containing these

Growing community of inventors

Biberach, Germany

Volkhard Austel