Roche Diagnostics Operations, Inc.

Boehringer Mannheim Gmbh

Roche Diabetes Care, Inc.

Boehringer Mannehim Gmbh

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Volker Unkrig

Joachim Hoenes

Carina Horn

Michael Marquant

Joerg Dreibholz

Holger Kotzan

Hans Wielinger

Christine Nortmeyer

Sylvia Saecker

Mihail-Onoriu Lungu

Manfred Augstein

Gregor Bainczyk

Volker Gerstle

Klaus Andreas Bauer-Espindola

Udo Zapf

Fritz Hindelang

Joachim Hones

Klaus-Dieter Steeg

Mihail Onoriu Lungu

Michael Marouant

A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.

Methods for detecting an analyte and performing a failsafe step in a body fluid using optical and impedance measurements

Test elements are disclosed for detecting at least one analyte concentration in a sample. The test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of at least one diffusable label.

Test elements for determining an analyte concentration that include correction information for at least one interfering variable

Methods are disclosed for detecting at least one analyte in a sample. The methods are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The methods correct for an interfering variable such as temperature and/or hematocrit in a test element system via a correction factor based upon diffusion of a diffusable label.

Methods of determining an analyte concentration that include correction information for at least one interfering variable

A device for sampling liquid samples is provided comprising a capillary-active channel, a sampling site, and a determination site. The capillary-active channel is configured for transporting a sample from the sampling site to the determination site. The capillary-active channel is substantially formed by a carrier, a cover and an intermediate layer located between the carrier and cover. The carrier protrudes beyond the cover in the area of the sampling site. The intermediate layer is displaced towards the back in the direction of the determination site in the area of the sampling site so that the carrier as well as the cover protrude beyond the intermediate layer. The device allows sample to be applied from above onto the exposed area of the carrier in the area of the sampling site and also allows sample to be applied from the side.

Sampling device for liquid samples

An electrochemical biosensor analysis system is provided for analyzing a sample liquid, comprising a biosensor having an electrode structure made of at least two electrodes, a test field, covering the electrode structure and capable of absorbing the sample liquid, and a defined sample application surface on the top side of the test field. The system also includes an analysis instrument comprising an evaluation unit for determining the desired analysis data. The analysis instrument comprises an AC resistance measuring device for measuring an AC resistance value between two electrodes of the electrode structure by means of an area compensation measurement. The measured AC resistance value is used, in the determination of the analysis data, as a measure of the partial area of the effective electrode structure area wetted by the sample liquid.

Electrochemical biosensor analysis system

The invention concerns a test device for analyzing especially a biological sample liquid comprising a composite body consisting of a plurality of layers of flat materials and a sample channel located in the composite body for transporting the sample liquid from an application site to a measuring site. According to the invention it is proposed that the composite body has a plurality of transport layers arranged in a stack-like manner between support layers for holding in each case sample channel.

Test device for analyzing a biological sample liquid

The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.

On-board control for analytical elements

A method and a corresponding system for error checking an electrochemical sensor having at least two electrodes and a liquid measuring medium applied thereto are disclosed. The method discloses determining a first admittance between a first set of electrodes of the sensor; determining a second admittance between a second set of electrodes of the sensor; determining a value using the first admittance and the second admittance; and displaying an error message if the value is out of a predetermined tolerance.

Method and system for error checking an electrochemical sensor

A method and a corresponding system for error checking an electrochemical sensor having at least two electrodes and a liquid measuring medium applied thereto are disclosed. The method involves determining a first admittance between a first set of electrodes of the sensor; determining a second admittance between a second set of electrodes of the sensor; determining a value using the first admittance and the second admittance; and displaying an error message if the value is out of a predetermined tolerance.

The invention concerns a method for the simultaneous colorimetric and electrochemical measurement of an analyte using an oxidizing enzyme and a chromogen A that accepts electrons from the enzyme which is characterized in that the chromogen A after reduction to A' reacts by coupling to a substance BX to form a colored substance A'B the concentratin of which is measured colorimetrically as a measure for the presence or amount of the analyte and in that an electrochemically measurable group X.sup.- is cleaved off during the coupling reaction the concentration of which is measured electrochemically as a measure for the amount of the analyte.

Method and agent for the simultaneous colorimetric and electrochemical

A sparingly soluble salt of a heteropoly acid is used for the determination of an analyte which is an aromatic amine rich in electrons or together with another substance leads to such an amine. The analyte is determined by means of the heteropoly blue color formed.

Use of a sparingly soluable salt of a heteropoly acid for the

The invention concerns a method for the colorimetric determination of an analyte by means of enzymatic oxidation with a PQQ-dependent dehydrogenase in the presence of an electron acceptor from the group of the electron-rich aromatic nitroso compounds by enzymatic reduction of the nitroso compound to an imino compound and detection of the imino compound by color formation. In addition the invention concerns a corresponding agent containing a PQQ-dependent dehydrogenase, an electon-rich aromatic nitroso compound as well as, if desired, a detection reagent for imino compounds. The invention in addition concerns novel nitrosoamino compounds which form colored quinone diimines on reduction as well as their use for the colorimetric enzymatic determination of an analyte.

Method for the colorimetric determination of an analyte with a

Test strip analysis system includes an analysis apparatus with a test strip holding device (3) and matching test strips. The test strip holding device (3) serves to position the test strip (4) in a defined position relative to a measuring unit (11). It includes a test strip seating device (20) and a guide for the test strip. Exact positioning with simple handling and without sophisticated mechanical elements is achieved by the fact that at least one part of the test strip seating device (20), in the area in which, in the measuring position, the front section (12) of the test strip is located, is formed as a support (24) which is offset in height relative to the middle plane (22) of the test field area (13). The test strip holding device (3) includes a pressure element (33) which, in the measuring position presses between the support (24) and the test field area (13) of the test strip (4) against the side (34) opposite the seating device ( 20) of the latter. The test strip (4) is consequently subjected to bending stress, whereby the particular distance of the at least one test field (6) from the measuring unit (11) is ensured.

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Ladenburg, Germany

Volker Unkrig