Hoechst Aktiengesellschaft

Behringwerke Aktiengesellschaft

Hoechst Aktiengesellschafat

Volker Teetz

Hansjorg Urbach

Rolf Geiger

Rainer Henning

Reinhard Becker

Bernward Scholkens

Wolfgang Konig

Hans Wissmann

Wolfgang Ruger

Helmut Heber

Holger Gaul

Dietrich Langner

Rainer Obermeier

Rainer Uhmann

Reinhard Eberle

Martin Bickel

Wolfgang Scholz

Heinrich Christian Englert

Dieter Mania

Gerhard Seibert

Hans-Wolfram Fehlhaber

Wolfgang Linz

Stephan Henke

Dietrich Brocks

Richard H Rupp

Herbert Kogler

Bimal N Ganguli

Jurgen K Sandow

Volkmar Gunzler

Hartmut Hanauske-Abel

Hermann Erich Karges

Hans G Alpermann

Gabriele Wiemer

Jurgen Ludwig

Sugata Chatterjee

Sukumar Chatterjee

Henning: Rainer

Hans Jorg Urbach

Georg Jager

Rudolf Knapp

Axel Friedrich

Hans Wissman

Hansj/o/ Rg Urbach

Deepak K Chatterjee

Rajendra K Jani

The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

Method of treating cardiac insufficiency using angiotensin-converting

The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their preparation and their use as medicaments.

Combination of angiotensin-converting enzyme inhibitors with calcium

Method of treating cardiac insufficiency

The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

Aminoacid derivatives of the formula I ##STR1## A , n, R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and salts thereof, a process for their preparation, pharmaceutical preparations based on these compounds, and their use as medicaments.

Aminoacid derivatives, a process for their preparation, agents

A combination of angiotensin-converting enzyme inhibitors and calcium antagonists for the treatment of proteinuria is disclosed. The invention relates to the prevention and therapy of proteinuria by administration of a combination of ACE inhibitor and calcium antagonist.

Use of a combination of angiotensin-converting enzyme inhibitor and

The invention relates to a pharmaceutical composition comprising an angiotensin converting enzyme inhibitor (trandolpril or pamipril) and a loop diuretic (Furosemide or piretanide), and to their use for the treatment of high blood pressure.

Pharmaceutical composition for the treatment of high blood pressure

The invention relates to the prevention and therapy of proteinuria by administration of a combination of ACE inhibitor and calcium antagonist.

The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each is hydrogen or an organic radical, and R.sup.4 and R.sup.5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

Method for the treatment of cardiac and of vascular hypertrophy and

The invention relates to a process for resolving racemic mixtures of bicyclic imino-.alpha.-carboxylic esters into the components by crystallization of diastereomeric salts, which comprises preparing the salts of the racemic esters with optionally active N-acylated R- or S-aminocarboxylic acids which contain a phenyl nucleus, recrystallizing them from an organic solvent, decomposing the precipitated, optically homogeneous diastereomeric salts in a manner known per se, and isolating the enantiomers and, where appropriate, converting the latter into the free acids by hydrolysis in a manner known per se. The invention also relates to optically pure compounds of the formula ##STR1## and to diastereomeric salts of these compounds, in which two of the radicals A, B.sup.1, B.sup.2 and C form a carbon chain and the other denote hydrogen, and R is an esterifying group.

Process for the resolution of racemates of optically active bicyclic

What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.

Octahydroindole-2-carboxylic acids

Decahydroisoquinoline carboxylic acids

Mersacidin, a cyclic peptide of the formula I ##STR1## has antibiotic activity.

Antibiotic, mersacidin, a process for the preparation thereof and the

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Hofheim am Taunus, Germany

Volker Teetz