Merz Pharma Gmbh & Co Kgaa

Volker Specht

Jürgen Frevert

The invention relates to a modified botulinum toxin comprising a natural heavy chain and a modified light chain, characterized in that the modification of the light chain resides in that it comprises (i) an extension of the chain on its N-terminus which has the structure -(C)-(tag)-(X)- in the direction from the N- to the C-terminal end, wherein

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The invention relates to a modified botulinum toxin comprising a natural heavy chain and a modified light chain, characterized in that the modification of the light chain resides in that it comprises (i) an extension of the chain on its N-terminus which has the structure &#x2014;(C)-(tag)-(X)&#x2014; in the direction from the N- to the C-terminal end, wherein

PEGylated mutated clostridium botulinum toxin

The invention relates to a modified botulinum toxin comprising a natural heavy chain and a modified light chain, characterized in that the modification of the light chain resides in that it comprises (i) an extension of the chain on its N-terminus which has the structure &#x2014;(C)-(tag)-(X)- in the direction from the N- to the C-terminal end, wherein

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Berlin, Germany

Volker Specht