Roche Diagnostics Operations, Inc.

Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Volker Klemt

Michael Grol

Klaus Hallermayer

Anneliese Borgya

Andreas Gallusser

Christoph Seidel

Helmut Lenz

Georg Hess

Urban Schmitt

Andrea Horsch

Juergen Spinke

Dietmar Zdunek

Ulrich Neumann

Alfons Nichtl

Dittmar Schlieper

Nicholas R Hoyle

Ursula Giesen

Gunter Muller

Michael Wiedmann

Andreas Galluser

The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. The epitopes recognized by the antibodies can slightly overlap.

Analytical sandwich test for determining NT-proBNP

The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.

Method of detecting a subfraction of proBNP

The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. One of these antibodies is directed at least against parts of the epitope of NT-proBNP comprising the amino acids 38 to 50. In addition, one of these antibodies is directed at least against parts of the epitope of NT-proBNP comprising the amino acids 1 to 37 or 43 to 76. The epitope recognized by the antibodies can slightly overlap.

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Weilheim, Germany

Volker Klemt