Warner-lambert Company

Godecke Aktiengesellschaft

Goedecke Aktiengesellschaft

Volker Ganser

Gerhard Satzinger

Johannes Hartenstein

Edgar Fritschi

Manfred F Herrmann

Hubert G Barth

Heinrich Bahrmann

Bernd Wagner

Ute Weiershausen

Wolfgang Steinbrecher

Gunter Wolf

Horst-Dietmar Tauschel

The use of benzothiazepine derivatives for the protection of lymphocytes in humans and higher mammals, especially in the treatment of acquired immune deficiency syndrome.

Use of benzothiazepine derivatives as lymphocyte protectors

The present invention provides compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are unsubstituted or substituted aromatic rings, Alk is a straight-chained or branched lower hydrocarbon chain and Z is a hydrogen atom, with the proviso that when Alk is a straight-chained hydrocarbon chain, Z can also be a lower alkylamino radical of the general formula II ##STR2## in which R.sup.3 and R.sup.4 are the same or different and are hydrogen atoms or straight-chained or branched lower alkyl radicals or R.sup.3 and R.sup.4, together with the nitrogen atom to which they are attached, can also form a ring optionally containing further hetero atoms; and the pharmacologically acceptable salts thereof. The present invention also provides an inventive process for preparing these compounds, as well as pharmaceutical compositions containing them. The compounds I may be used in the therapy of inflammations and they are free of gastrointestinal side effects.

2-pyrrolin-3-carbonitril-derivatives, pharmaceutical compositions

2-Pyrrolin-3-carbonitrile derivatives, and pharmaceutical compositions

2-Alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles and pharmaceutically acceptable acid addition salts, processes for their preparation and formulation into pharmaceutical compositions as well as their activity as thrombocyte aggregation-inhibitors are described. The compounds are thus useful for the prophylaxis and therapy of thrombotic states.

2-Alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles, compositions and

The present invention provides 5,6;8,9-tetrahydro-7H-dibenz(d,f)azonine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are hydrogen or halogen atoms or lower alkyl or alkoxy radicals, R.sup.3 is a hydrogen atom or a lower alkyl radical, R.sup.4 is a hydrogen atom or a lower alkyl or alkanoyl radical and n is 1 or 2; and the pharmaceutically acceptable salts thereof formed with inorganic and organic acids; but excluding 6-benzyl-2,12-dimethoxy-1-hydroxy-7-methyl-5,6;8,9-tetrahydro-7H-dibenz(d, f)azonine in which case R.sup.1, R.sup.2 and R.sup.4 are hydrogen, n is 1 and R.sup.3 is methyl. The lower alkyl, alkanoyl and alkoxy radicals are straight chained or branched radicals containing 1 to 5 carbon atoms. The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them.

5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonines

Novel azocine derivatives and a method for their preparation are disclosed. The compounds display analgesic effects in mammals.

Azocine analgesics and method for their preparation

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Freiburg, Germany

Volker Ganser