Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu

Spofa United Pharmaceutical Works

Vojtech Pujman

Jiri Krepelka

Karel Rezabek

Miroslav Semonsky

Antonin Cerny

Milan Melka

Stanislava Pokorna

Ruzena Reichlova

Rudolf Kotva

Iva Vancurova

Oskar Andrysek

Slavjanka Cernochova

Hana Vesela, Deceased

Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.

Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for their

5-Carboxyalkyl-2-iminobarbituric and 5-carboxyalkyl-2-thioxobarbituric acids and derivatives thereof are prepared either by condensation of a triester of a tricarboxylic acid with a thio or imino diamide to yield an ester which is saponified, the desired compound being obtained by liberation with a mineral acid from an ammoniacal medium containing the saponified ester. Alternatively, free tricarboxylic acids may be substituted for the triesters. The compounds described herein have evidenced a therapeutic effect in animals having transplanted tumors, and have inhibited tumor growth and lengthened the life of animals and humans.

Derivatives of carboxyalkyl imino- and thioxo-barbituric acids

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Prague, Czechia

Vojtech Pujman