Pall Corporation

Merck + Co., Inc.

Vlado I Matkovich

Thomas J Bormann

Thomas C Gsell

Frank R Pascale

Gerard R DelGiacco

David B Pall

Mladen Franovic

Peter J Degen

David J Rosenberg

Eric J Krasnoff

Keith S Morris

Samuel T Wortham

Duane Piechocki

Benjamin Janes Beck

Isaac Rothman

Harvey Brandwein

YoungMihn Kim

Thomas Burchard

Graham Desmond Lowe

Stephen Guerrera

Thomas E Schlaudecker

Roger E Page

Jerold Martin

Sidney Krakauer

Martin W Henley

Gerard R Del Giacco

Stephen Hart

Gerald R Delgiacco

A method of making a sterile connection comprises mating a first fitting having an aperture and a second fitting having an aperture, removing first and second strip out layers from between the end surfaces of sealed first and second resilient sealing members, and contacting the end surfaces of the resilient sealing members to provide fluid communication between the aperture of the first fitting and the aperture of the second fitting. A connector assembly comprises first and second fittings, a stem mounted for axial movement through the first fitting into the second fitting, and a deformable locking device which selectively prevents axial movement of the stem in the first fitting.

Methods for making a connection

A connector assembly and a fluid system or device comprises a connector assembly which includes first and second fittings, each fitting having an aperture, a first cap, and a stem disposed in the aperture of the first fitting. In various embodiments of the invention, the connector assembly further comprises a socket cooperatively arranged with one of the first and second fittings and at least one resilient sealing member. A method for making a connection includes removing a cap, mating first and second fittings, removing a stripout layer, and establishing a fluid flowpath through the first and second fittings.

Connector assemblies and methods for making a connection

A connector or a connector assembly comprises a fitting, a resilient sealing member, a plurality of protrusions, and a removable stripout layer. The fitting includes a socket. The protrusions extend from the fitting and are connectable to a mating connector. The resilient sealing layer, which is disposed in the socket of the fitting, includes a hollow body having opposite open ends and an internal passage extending between the open ends. The removable stripout layer is movable between a first position in which the stripout layer overlies an end of the resilient sealing member and a second position in which the stripout layer is removed from the end of the resilient sealing member.

Connector assembly

Connectors, connector assemblies, fluid systems, and method for making a connection

A connector assembly and a fluid system or device comprise a connector assembly which includes first and second fittings, each fitting having an aperture, and a stem disposed in the aperture of the first fitting. In various embodiments of the invention, the connector assembly may further comprise a socket cooperatively arranged with one of the first and second fittings, at least one resilient sealing member, a sealing layer joined to the socket or covering the resilient sealing member, and/or a deformable locking device. A method for making a connection includes mating a first fitting having an aperture and a second fitting having an aperture without fluid within the first and second fittings, establishing a fluid flowpath through the first and second fittings by advancing a stem having a head through the aperture of the first fitting into the aperture of the second fitting, and establishing fluid flow through the first and second fittings by opening a fluid blocking mechanism.

Connector assemblies, fluid systems, and methods for making a connection

A fluid delivery system includes a connector assembly and a container for holding fluids. The connector assembly includes a first fitting defining a first aperture and a second fitting that is couplable to the first fitting and defines a second aperture. The container for holding fluids including a fitment, wherein one of the first and second fittings is directly coupled to the fitment.

Fluid delivery systems and methods and assemblies for making connections

A fluid delivery system includes a connector assembly and a container. The connector assembly includes a first fitting defining a first aperture, a second fitting that is couplable to the first fitting and defines a second aperture, and a removable contamination containment layer sealing at least one of the first and second apertures. One of the first and second fittings is associated with the container.

A device ( ) such as a drip chamber that can be filled to a predetermined level is disclosed. The device comprises a housing ( ) and a porous medium ( ), wherein the porous medium allows gas to pass therethrough.

Priming system

A method for automatically processing a biological fluid is disclosed. The method includes the steps of obtaining a container having a biological fluid therein, providing a first signal and communicating with an automated control arrangement to establish flow of at least a portion of the biological fluid along a fluid flow path through a leukocyte depletion medium, providing a second signal and communicating with the automatic control arrangement to terminate flow along the fluid flow path wherein providing the second signal includes sensing the back pressure in the fluid flow path or the flow rate through the leukocyte depletion medium.

Automated method for processing biological fluid

A biological fluid filter assembly (,) including a plurality of porous media (,) and essentially lacking a solid partition between the media is disclosed. Preferably, the assembly has a space (,) between the media (,). The filter assembly is especially suitable for depicting leukocytes from a biological fluid such as packed red cells, and can be used to deplete leukocyts from two or more units of biological fluid. A method of using the filter assembly is also provided.

Multiple element filter and method of using therefor

An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly, and an automated control arrangement coupled to at least one of the pressure differential generator and the biological fluid processing assembly. The automated system may include a porous medium, such as a red cell barrier medium, a leukocyte depletion medium, or a combination red cell barrier/leukocyte depletion medium. The automated system may also include a sensor producing a signal reflecting a parameter of fluid flow.

Automated system and method for processing biological fluid

Biological fluid processing assemblies having a gas inlet and/or a gas outlet are disclosed.

Venting system

A connector assembly includes a first fitting defining a first aperture, and a second fitting couplable to the first fitting and defining a second aperture. In some embodiments, each of the first and second fittings includes a sealing layer sealing its aperture. In other embodiments, each of the first and second fittings includes a removable layer overlying its aperture. The connector assembly may include a stem member which is mounted in the first fitting and includes a head axially movable into the aperture of the second fitting.

A connector assembly includes first and second fittings including first and second membrane assemblies, respectively, and a stem member. A fluid delivery system includes a connector assembly, a container for holding fluids and tubing which couples the container to one of the first and second fittings. A method for making a contaminant-free connection comprises mating first and second fittings, and establishing a fluid flow path through the first and second fittings. The systems, assemblies and methods according to the invention may be used, for example, to handle a biological fluid while maintaining the fluid free of viable contaminating microorganisms or preserving its sterility.

Growing community of inventors

Glen Cove, NY, United States of America

Vlado I Matkovich