Eurand Pharmaceuticals, Ltd.

Rudjer Boskovic Institute

Chirallica D.o.o.

Societa' Cooperative Centro Ricerche Polytech a Responsabilitia' Limitata

Vladimir Vinkovic

Darko Kontrec

Luciano Navarini

Vitomir Sunjic

Paolo Mariotti

Luca Stucchi

Goran Landek

Vitomir Sunjić

New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the support surface through the allylic double bond. Such obtained materials allow enantioseparation of racemates or enantiomerically enriched compounds. These chiral stationary phases can be used as fillings in chromatographic columns for enantiomer separation of naproxen type drugs and other similar non-steroidal anti-inflammatory drugs (NSAID) by means of high performance liquid chromatography on both the analytical and preparative scale.

Chiral stationary phases for chromatography based on aromatic allyl amines

The invention describes new hyaluronan derivatives where the hydroxyl groups are esterified or carbamoylated in amounts ranging from 0.01% to 100% and the carboxyl groups are either totally or partially esterified with alcohols or are in the form of salt.

Derivatives of hyaluronan

The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the preparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.

Chiral stationary phases based on derivatives of 4-amino-3,5-dinitrobenzoic acid

The present invention describes new chiral stationary phases and optically active compounds therein contained. The optically active compounds contained in the stationary phases are represented by the formula of structure (I), containing at least one asymmetric carbon atom, and a substituent acting as a spacer. The stationary phases of the present invention are useful in the preparation of chromatographic columns useful for the separation of enantiomers.

Chiral stationary phases for enantiomers separation and their preparation

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Zagreb, Croatia

Vladimir Vinkovic