Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Roche Operations Ltd.

Boehringer Mannheim Gmbh

Corange International Limited

Roche Diabetes Care, Inc.

F. Hoffmann-la Roche Ag

Vladimir Svetnik

David W Burke

Terry Allen Beaty

Lance Scott Kuhn

Michael Lee Brown

Robert A Parks

Raghbir Singh Bhullar

Bradley E White

Paul G Ritchie

Sandy Mark Richards

Nigel A Surridge

Brian S Hill

Christopher L Belisle

James R Parker

Richard W Wilson

Carol Jane Batman

Paul Douglas Walling

Robert G Davies

Timothy L Ranney

Kurt Klem

Patricia A Hopkinson

Lynne Denise Sly

Nancy Kennedy Byrd

Richard J Kasle

Stefan Weinert

Melani G Sullivan

Marvin W Glass

Leonard Allen Vetsch

Michael Steven Ray

Greg Paul Carpenter

William Brothers

Christopher Louis Belisle

Lance S Khun

Kurt Gerard Klem

Lance S Kuhn

Nigel Anthony Surridge

Melani Sullivan

Robert Glenn Davies

Robert Anthony Parks

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

System and method for analyte measurement

A system for testing for analytes in a sample of biological fluid includes a test strip that defines a cavity for receiving the sample. At least two sets of electrodes are adjacent the sample cavity, including one for measuring one property of the sample, and another for measuring one or more other properties of the sample, such as temperature and/or the presence or magnitude of confounding variables. The measurements are combined to yield the desired result. At least one set of working and counter electrodes each have a plurality of elongated 'fingers' interdigitated with those of the other electrode in the set. The gaps between fingers can be quite small, so that the two electrode sets together can operate in a small measurement volume of sample. Additional electrodes can be included that measure the presence or sufficiency of the sample, and additional traces on the strip can act as configuration identifiers.

Devices and methods relating to electrochemical biosensors

Control and calibration solutions are described that provide control and calibration data that is recognized by a test meter allowing the meter to segregate the control and calibration data from regular test data. Recognition and segregation of the control and calibration data can occur automatically with no additional input from the meter's user. Methods for use of the solutions are also provided.

Control and calibration solutions and methods for their use

A sensor strip comprises an electrode substrate, an electrode set, on the electrode substrate, and a heat conducting layer, on the electrode substrate opposite the electrode set. A sensor instrument for use with this sensor strip comprises a temperature sensor, at a side of a gap for accepting the sensor strip, opposite electrical contacts. The invention provides an accurate determination of the temperature of a sample.

Sensor system

System and method for determining a temperature during analyte measurement

System and method for analyte measurement using AC excitation

System and method for analyte measurement using AC phase angle measurements

Thermally conductive sensor

An apparatus and method for determining the concentration of a medically significant component of a biological fluid comprise providing a cell supporting a chemistry which reacts with the medically significant component. Placement of first and second terminals of the cell in contact with first and second terminals, respectively, of an instrument permits the instrument to assess the reaction. The instrument determines a first response of the cell to a first signal, and determines based upon the first response whether to proceed with the determination of the concentration of the medically significant component of the biological fluid. If the determination is to proceed, the instrument determines the type of sample that has been applied. If the sample is a sample of a particular type, the instrument determines a first correction value based upon the cell's response to the third signal and combines the correction value with the result of the reaction assessment to produce an indication of the concentration of the medically significant component in the sample.

Meter and method of using the meter for determining the concentration of a component of a fluid

An instrument ( ) has a well ( ) for receiving a dry cell ( ), an opening ( ) through which a first connector ( ) is exposed to the well ( ), and a boss ( ) adjacent the opening ( ). The boss ( ) precludes the wrong terminal of the dry cell ( ) from engaging the first connector ( ) when the dry cell ( ) is inserted into the well ( ) in incorrect orientation. A second connector ( ) includes a base ( ), a first leg ( ) resiliently connected to and extending away from the base portion, a second leg ( ) resiliently connected to and extending away from the first leg ( ), and a third leg ( ) resiliently connected to and extending away from the second leg ( ) and toward the first leg ( ). A display ( ) for the instrument ( ) has a lens ( ) having a substantially transparent substrate with a polyurethane coating. The instrument housing has first and second portions. At least one locator pin ( ) extends from one ( ) of the housing portions and at least one complementary socket ( ) extends from the other ( ) of the housing portions for receiving the pin ( ) to maintain the first ( ) and second ( ) portions in assembled orientation.

Apparatus and method for determining the concentration of a component of a sample

A biosensing meter is provided that determines a value of an analyte in a biological sample. The meter employs an algorithm for determining the analyte value, which value is dependent upon ambient temperature about the biological sample when it is present in a reaction zone. The biosensing meter includes a processor and a temperature sensor. The temperature sensor is positioned within the meter's structure and thereby exhibits a delayed response to changes in the ambient temperature. The meter performs a temperature estimation method to overcome the delayed temperature response. The method commences by the meter repetitively and periodically acquiring temperature readings from the temperature sensor when the biosensing meter is both in an on state and in an off state. When the meter is in the on state, the algorithm estimates the ambient temperature by employing at least two most recent temperature readings and extrapolating therefrom to achieve an ambient temperature estimate. Temperature readings are acquired by the meter at first intervals when the meter is in the off state and at second, shorter intervals when the meter is in the on state, the temperature extrapolations only occurring when the meter is in the on state.

Biosensing meter with ambient temperature estimation method and system

A biosensing meter receives a sample strip that includes electrically isolated sense and excitation electrodes bridged by a reaction zone. When a drop of biological sample fluid is placed in the reaction zone, a plurality of fail/safe tests are performed. A drop size test is performed by a circuit that detects the size of the drop placed in the reaction zone. The circuit both detects that a drop has been placed in the reaction zone and further measures a test current level, after a delay, to determine that the drop size is sufficient to enable hydration of reactants in the reaction zone. Subsequently, during the reaction, a 'delta' current change is measured at succeeding sample time. This test measures the difference between succeeding current samples during a measurement time. If each succeeding sample is not less than preceding sample by a delta value, a determination is made that the current is not monotonically decreasing and the test is aborted. At the termination of the measurement time, a current sum test is performed wherein a processor calculates a linear sum of all sample test currents and calculates a ratio between that sum and the last current sample. If that ratio matches a pre-calculated constant for the Cottrell relationship, then it is known that the measurement values exhibit the Cottrell relationship.

Biosensing meter with fail/safe procedures to prevent erroneous

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Morristown, NJ, United States of America

Vladimir Svetnik