Genentech, Inc.

F. Hoffmann-La Roche Ag

Vladimir Ramirez-Carrozzi

Tracy Staton

Joseph R Arron

Rajita Khosla

Brian Yaspan

Amy Dressen

David Choy

The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the /L1RL1gene, the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the /L1RL1gene the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2.

Therapeutic and diagnostic methods for IL-33-mediated disorders

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Millbrae, CA, United States of America

Vladimir Ramirez-Carrozzi