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Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk

Vsesojuzny Kardiologichesky Nauchny Tsentr

Vladimir P Torchilin

Vladimir N Smirnov

Evgeny I Chazov

Alexandr V Maximenko

Grigory M Grinberg

Alexandr A Mishin

Karel Martinek

Ilia V Berezin

Boris V Moskvichev

Igor M Tereshin

Gennady P Samokhin

Gersh I Kleiner

Agris Z Skuya

Alexandr M Klibanov

Viktor S Goldmakher

Elena G Tischenko

Urokinase derivatives covalently bound to fibrinogen

A method of preparing a polysaccharide derivative of fibrinolysin which comprises reacting fibrinolysin with dextran dialdehyde having a molecular mass of from 20,000 to 110,000 at a pH of from 8.0 to 9.5 and at a temperature within the range of from 5.degree. to 30.degree. C. with the formation of a covalent bond; the resulting fibrinolysin derivative is reduced with sodium borohydride and isolated.

Dextran derivative of fibrinolysin

A heat-resistant water soluble derivative of urokinase is prepared which comprises urokinase covalently bonded to a copolymer of acrylamide and acrylic acid having a molecular weight of 10,000 to 200,000 and a content of acrylic acid of 1% to 2%. The derivative contains 15% to 35% urokinase and has an esterase and amidolytic activity of from 10% to 80%.

Heat-resistant water soluble urokinase derivative

A method for producing a visible image of an object is disclosed in which a fermental plate is illuminated with ultrasonic waves and a latent image of the object is therefore produced therein which is developed using a solution of chromogenic substrates, comprising, for example, hydrogen peroxide and a water-soluble aromatic amine. An apparatus to practice the disclosed method comprises an ultrasonic generator to generate ultrasonic waves illuminating the object, a fermental plate to receive and convert the ultrasonic waves passed through the object to a visible image, and a tray filled with a developer to develop the latent image of the object in the fermental plate.

Method and apparatus for producing visible image of object

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Moscow, Russia

Vladimir P Torchilin