Synthetic Genomics, Inc.

Codex Dna, Inc.

Vladimir N Noskov

Ray-Yuan Chuang

J Craig Venter

Hamilton O Smith

Daniel Glenn Gibson

Clyde A Hutchison

John Irvin Glass

Bogumil J Karas

Carole Lartigue

Sanjay Vashee

Charles E Merryman

Gwynedd A Benders

Krishna Kannan

Lin Ding

Chuck Merryman

Mikkel A Algire

John I Glass

Kim S Wise

Clyde A Iii Hutchison

Daniel G Gibson

Methods for generating synthetic genomes, for example synthetic genomes having desired properties or viable genomes of reduced size, are disclosed. Also disclosed are synthetic genomes produced by the methods disclosed herein and synthetic cells containing the synthetic genomes disclosed herein.

Generation of synthetic genomes

Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.

Methods for cloning and manipulating genomes

Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.

Growing community of inventors

Montgomery Village, MD, United States of America

Vladimir N Noskov