Vuab Pharma A.s.

Agra Group, A.s.

Vub Pharma A.s.

Vladimir Kysilka

Petr Kacer

Libor Cerveny

Jiri Kopenec

Jan Mengler

Jen Mengler

Karel Havlovic

Lucie Potucka

Jiri Krepelka

Tomas Kalisz

The invention relates to a new platinum (IV) complex with substantially increased antitumor efficacy. The invention further discloses a process for preparing of said complex and a pharmaceutical composition for the therapy of tumor diseases containing said complex.

Platinum (IV) complex with increased anti-tumor efficacy

The present invention relates to a process for preparing a trichloroammineplatinate salt by reacting a tetrachloroplatinate salt in aqueous solution in the presence of ammonium chloride and an alkali chloride with one or more carbonate salts selected from the group consisting of potassium, sodium and ammonium carbonate while keeping the pH value below 7 during the reaction; the product obtained therein and a use thereof.

Process for preparing trichloroammineplatinate salt and the products obtained therein

The invention provides a process for preparing N-(hydrocarbyl)phosphoric or thiophosphoric triamides with substantially improved yields and purity. Two equivalents of hydrocarbylamine are used in the reaction with phosphoryl or thiophosphoryl chloride and then with ammonia in an aromatic solvent. The invention further relates to N-(hydrocarbyl)phosphopric or thiophosphoric triamides having the purity of at least 98% wherein R is a hydrocarbyl group and X is O or S.(RNH)(NH)P=X &#x2003;&#x2003;(I).

Process for preparing N-(hydrocarbyl) phosphoric or thiophosphoric triamides

The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy.

Process for the preparation of an oxaliplatin

Process for the preparation of an oxaliplatin preparation

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Brno, Czechia

Vladimir Kysilka