Pacira Pharmaceuticals, Inc.

Recode Therapeutics, Inc.

Vladimir Kharitonov

Ernest George Schutt

Soroush M Ardekani

Louie Daniel Garcia

Stephanie M Kurz

Kathleen Dunne Albright Los

Katherine Stone

Kathy Los

Roy Winston

Mirko Hennig

Brandon A Wustman

Jackson Eby

Rumpa Bhattacharjee

Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled to a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.

Compositions and methods for targeted delivery to cells

In some embodiments provided herein is a method of treating pain, the method comprising administering into the subject

Treatment of pain by administration of sustained-release liposomal anesthetic compositions

In some embodiments provided herein is a method of treating pain, the method comprising injecting into the subarachnoid space of the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.

Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions

Embodiments of the present disclosure are related to multivesicular liposome formulations encapsulating zinc meloxicam complex microparticles. Methods of making the zinc meloxicam complex microparticles and administering the zinc meloxicam complex microparticles encapsulated in multivesicular liposome formulations and their use as medicaments are also provided.

Zinc meloxicam complex microparticle multivesicular liposome formulations and processes for making the same

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San Diego, CA, United States of America

Vladimir Kharitonov