University of California

Vladimir Kepe

Jorge R Barrio

Nagichettiar Satyamurthy

Gary W Small

Ernest M Wright

Bruce A Hirayama

Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled withF,I, orI, or free hexoses radiolabeled withF,I, or. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.

Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease

Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled withF,I,I,I, orC. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.

Growing community of inventors

Los Angeles, CA, United States of America

Vladimir Kepe