Wyeth

Equistar Chemicals, LP

Vladimir Dragan

Jean Louise Helom

John Potoski

Ramesh Krishnamurti

Bogdan Kazimierz Wilk

Arwinder Singh Nagi

Arkadiy Zinoviy Rubezhov

Ramarao S Chatlapalli

Xinxu Shi

Wayne G McMahon

Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.

Purified form of tanaproget

The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.

Processes and compounds for the preparation of substituted naphthylindole derivatives

The present invention provided an improved method for preparing a boratabenzene derivative. The invention includes an improved preparation of 1,4-pentadiyne, 1-haloboracyclohexa-2,5-diene, and 1-methylboracyclohexa-2,5-diene intermediates. These compounds are chemically labile and are not directly isolated from solution. Furthermore, the invention discloses an improved preparation of 1,1-dialkylstannacyclohexa-2,5-diene, another intermediate useful for preparing boratabenzene derivatives.

Method for preparation of boratabenzene derivatives

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Chester, NY, United States of America

Vladimir Dragan