Ceskoslovenska Akademie Ved

Carlton Medical Products Limited

Vladimir Chytry

Karel Ulbrich

Jiri Strohalm

Jaroslav Kalal

Jiri Vacik

Jaroslav Drobnik

Jindrich Kopecek

Jinrich Kopecek

Pavla Rejmanova

Ruth Duncan

Blanka Rihova

John B Lloyd

A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety, and an optional cross-linkage, comprises:

Synthetic polymeric drugs

The invention relates to copolymers based on N-substituted acrylamides, N-substituted methacrylamides and N,N-disubstituted acrylamides and to a method for their manufacturing, which copolymers are prepared under conditions when the phase separation takes place. The resulting copolymer contains reactive groups and serves as the intermediate for preparation of biologically active compounds (enzymes, hormones, drugs, etc.) bonded to the polymer. The procedure according to the invention enables to prepare porous polymers suitable as separation barriers (membranes) or column packings for gel or affinity chromatography, if the polymerization is carried out in the presence of a divinyl component.

Copolymers based on N-substituted acrylamides, N-substituted

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Prague, Czechia

Vladimir Chytry