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Adisseo Ireland Limited

Vivien Henryon

Patrick Rey

Robert Huet

Jean-Michel Joerger

Jerome Monbrun

Vincent Gerusz

Jean-Claude Le Thiesse

Francois Moreau

Etienne Airiau

Dmytro Atamanyuk

Sylvain Aubry

François Moreau

Jérôme Monbrun

A method for preparing a compound of formula (I)   

Method for synthesising vitamin A

A method for preparing dehydro-cyclofarnesal from dehydro-farnesal by cyclization in the presence of an acid may include the dehydro-farnesal being obtained from the farnesal by dehydrogenation and may further includes the cyclization being carried out in the presence of an acid selected from Lewis acids, Bronstedt acids, and zeolites. The synthesis of vitamin A using this method further includes the conversion of dehydro-cyclofarnesal into vitamin A.

The invention relates to compounds of formulae (Ia), (Ib) or (Ic) wherein, Aand A, identical or different, are H, (C-C) alkyl, (C-C) fluoroalkyl, (C-C) alkenyl, (C-C) alkynyl, (C-C) alkyl-OR, (C-C) alkyl-SR, (C-C) alkyl-NRR, OR, SR, NRR, or COR; Ais H, OH or form a carbonyl with A; Ais H, OH or form a carbonyl with A; Ais H, CRROH, F, OH or forms a double bond with X in the case where X is CH; Ais H or F; X is CH, CHF, CF, CHOH, O, S, NRor a simple bond, or X is CH in the case where Aforms with X a double bond; Y is P(O)(OR)(OR) or P(O)(OR)(NRR); V is O or S; Ais H, (C-C) alkyl, (C-C) fluoroalkyl, (C-C) alkenyl, (C-C) alkynyl or (C-C) alkyl-OR; Ais OH or H, Rand R, identical or different, are H, (C-C) alkyl, (C-C) fluoroalkyl, (C-C) alkyl-OH or (C-C) alkyl-O&#x2014;(C-C) alkyl; and their addition salts thereof with acids and bases, their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity. 

Antibacterial compounds and biological applications thereof

The invention concerns a method for preparing a complex of an acid chosen from among methionine, 2-hydroxy-4-methylthiobutanoic acid (HMTBA) and lactic acid, and of at least one metal, starting from said acid and a mineral metal source, wherein the acid is caused to react with the mineral metal source in an extruder.

Method for preparing a complex of an acid and a metal

The invention relates to a method for preparing an amino acid, or its salts, from 2-aminobutyrolactone (2ABL), said amino acid fitting the formula I, XCHCHCHNHCOOH, wherein X is such that Xrepresents a nucleophilic ion, according to which N-carboxylation of 2-aminobutyrolactone (2ABL) is achieved with carbon dioxide, and the thereby obtained 2ABL carbamate is reactive with an XH reagent or its salts.

Method for preparing an amino acid from 2 aminobutyrolactone

The invention relates to a method for preparing 2-hydroxybutyrolactone (2HBL) from a compound or its salt or its oligomers, said compound fitting formula (I)CH&#x2014;S&#x2014;CHCHCR1R2R3

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Lyons, France

Vivien Henryon