Centro De Ingenieria Genetica Y Biotechnologia

Centro De Ingenieria Genetica Y Biotecnologia

Viviana Falcón Cama

Osvaldo Reyes Acosta

Glay Chinea Santiago

Luis Javier González López

Raimundo Ubieta Gómez

Lila Rosa Castellanos Serra

Osmany Guirola Cruz

Hilda Elisa Garay Pérez

Vivian Huerta Galindo

Norailys Lorenzo Perez

Taimi Emelia Paneque Guerrero

Celia Berta Fernandez Ortega

Marta Dubed Echevarria

Mónica Sarría Núñez

Ariana Barberá Betancourt

Leonor Margarita Navea Leyva

Dionne Casillas Casanova

Carlos Antonio Duarte Cano

Alejandro Miguel Martín Dunn

Mariela Vázquez Castillo

Dianne Pupo Gómez

Alexis Yero Díaz

Anna Caridys Ramírez Suárez

Gabriel Jesús Márquez Perera

Rocío Garateix Suárez

Karen Alvarez Pérez

Sonia González Blanco

Gabriel Ramón PADRÓN Palomares

María Del Carmen Domínguez Horta

Ivón Menéndez Valdés

The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.

Beta hairpin peptides having antiviral properties against Dengue virus

The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton.

Method for inhibiting HIV replication in mammal and human cells

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Playa La Habana, Cuba

Viviana Falcón Cama