Centro De Ingenieria Genetica Y Biotecnologia

Vivian Morera Cordova

Gabriel Ramón Padrón Palomares

Norailys Lorenzo Perez

Nelia López Marin

Ariana Barberá Betancourt

Ariadna Hernández Garcia

Carelia Cosme Diaz

Nelson J Merino Garcia

Ariel Vázquez Bonachea

José Suárez Alba

Ariel Vazquez Bonachea

Ariadna Hernandez Garcia

Nelia Lopez Marin

Alexis Musacchio Lasa

Luis Saturnino Herrera Martinez

Anabel Alvarez Acosta

Maria Del Carmen Dominguez Horta

Silian C Leon

Hernan R Campana

Bianca M Garcia Garcia

Emilio M Clark

Julio M Delgado Boada

Maria E Gonzalez Martinez

Efrain R Jiminez

Rossana G Fernandez

Jose A Cremata Alvarez

Dania M Curbelo

Carlos F Patron

Julio R Maso

Manuel R Raices Perez-Castaneda

Evelin C Menendez

Maria Del Carmen Domínguez Horta

Selman H Sosa

Silva Rodriquez

Saturnino H Martinez

Guillen Nieto

Lidia I Perez

Beatriz T Santos

Sonia G Blanco

Jesus A Del Valle Rosales

Edelgis C Rodriquez

Juan M Grillo

Nelson J Merino García

Ariel Vásquez Bonachea

Ariadna Hernández García

Carelia Cosme Díaz

Nelia López Marín

Gabriel Ramón PADRÓN Palomares

Maria Del Dominguez Horta

Maria Dominguez Horta

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

Altered peptide ligand derived from HSP60 and pharmaceutical compositions

Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions

A method for the isolation and expression of a gene coding for dextranase of the fungus Penicillium minioluteum. This enzyme of fungal origin is produced by expression at high levels in yeast. For this purpose, a cDNA copy of the mRNA coding for dextranase enzyme of the Penicillium minioluteum fungus was isolated and sequenced. This cDNA was transfered into Pichia pastoris cells. Recombinant yeasts capable of secreting dextranase to the culture medium were obtained thereby. The dextranase enzyme obtained can be used, e.g. in the sugar industry to hydrolyze the dextran in cane juices to increase the sugar production.

Dextranase enzyme, method for its production and DNA encoding the enzyme

The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64,000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used for the transformation of a host microorganism. The technical object pursued with the invention is the identification of a nucleotide sequence coding for a highly conserved and common protein for the majority of pathogenic Neisseria strains, the production of this protein with a high level of purity and in commercially useful amounts using the recombinant way, so that it can be used in diagnostic methods and vaccine preparations with a broad immunoprotection spectrum.

Nucleotide sequence coding for an outer membrane protein from Neisseria

Growing community of inventors

Ciudad de la Habana, Cuba

Vivian Morera Cordova