Organovo, Inc.

Oregon Health & Science University

Vivian A Gorgen

Sharon C Presnell

Benjamin R Shepherd

Justin B Robbins

Deborah Lynn Greene Nguyen

Shelby Marie King

Stephen L Pentoney, Jr

Keith Murphy

Harry Scott Rapoport

Frank C Lin

Vaidehi Joshi

Ellen Langer

Brittany Allen-Petersen

Rosalie Sears

Samir Damle

Clay Platt

Stephen Pentoney

Deborah Lynn Nguyen

Frank Lin

Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.

Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Engineered, living, three-dimensional liver tissue constructs including: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct free of pre-formed scaffold. Also disclosed are arrays and methods of making the same.

Engineered liver tissues, arrays thereof, and methods of making the same

Engineered, living, three-dimensional liver tissue constructs comprising: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct. In some embodiments, the constructs are characterized by having at least one of: at least one layer comprising a plurality of cell types, the cell types spatially arranged relative to each other to create a planar geometry; and a plurality of layers, at least one layer compositionally or architecturally distinct from at least one other layer to create a laminar geometry. Also disclosed are arrays and methods of making the same. Also disclosed are engineered, living, three-dimensional liver tissue constructs for use in the augmentation or restoration of one or more liver functions, by in vivo delivery of tissue or utilization of tissue in an extracorporeal device.

Described herein are improvements to bioprinting technology that facilitate automation of tissue and organ fabrication processes.

Automated devices, systems, and methods for the fabrication of tissue

Growing community of inventors

San Diego, CA, United States of America

Vivian A Gorgen