Council of Scientific and Industrial Research

Vivek Tirunelveli Natarajan

Rajesh Sudhir Gokhale

Parul Ganju

Dumbala Srinivasa Reddy

Balamkundu Seetharamsingh

The invention describes a method to modulate melanosome maturation process in melanocytes. Further, it describes a method to reversibly alter the process of pigmentation in the human epidermal skin. The method targets melanosome maturation and its transfer to keratinocytes, which are key processes involved in the pigmentation for its potential use in predictable and controlled regulation of pigmentation in human skin.

Method to modulate pigmentation process in the melanocytes of skin

A 1,2,3 triazole-thiazole compound of formula (I) or pharmaceutically acceptable salt thereof, process for its preparation, its pharmaceutical composition and method for the treatment for stalling vitiligo spread or provide prophylactic benefit to individuals with vitiligo predisposition.

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Delhi, India

Vivek Tirunelveli Natarajan