Theravance, Inc.

Xenoport, Inc.

Vivek Sasikumar

Paul Ross Fatheree

Seok-Ki Choi

Robert Murray McKinnell

Ryan Hudson

Keith Jendza

Mark A Gallop

Roland Gendron

Feng Xu

Usha Dilip

The invention is directed to compounds of formula I: wherein Ar, r, R, X, and Rare as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have ATreceptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.

Dual-acting antihypertensive agents

The invention relates to compounds having the formula: wherein: Ar, r, R, Z, X, and Rare as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have ATreceptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

Growing community of inventors

Morrisville, NC, United States of America

Vivek Sasikumar