Aptalis Pharmatech, Inc.

Adare Pharmaceuticals, Inc.

Vivek Purohit

Gopi M Venkatesh

Jin-Wang Lai

Nehal H Vyas

Gopi Venkatesh

The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR particles each comprise a core coated with a TPR layer; the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer; the RR particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt. % of the weakly basic, poorly soluble drug in about 5 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2&#x2014;paddles@50 RPM and a two-stage dissolution medium at 37&#xb0; C. (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).

Growing community of inventors

East Lyme, CT, United States of America

Vivek Purohit