Depuy Synthes Products, Inc.

Neucoll, Inc.

Collagen Corporation

Cohesion Technologies, Inc.

Codman & Shurtleff, Inc.

Vivek N Shenoy

Hassan A Serhan

Thomas M DiMauro

Michael Andrew Slivka

George H Chu

Mohamed Attawia

Melissa Grace

Thomas G Ferro

Jeff E Yeung

Alonzo D Cook

John T Rice

Robert E Sommerich

Jacqueline Anne Schroeder

Scott Bruder

James J Cassidy

George R Martin

Joel S Rosenblatt

Matthew J Halvorsen

Timothy T Revak

Melissa K C Brown

Laurel R Macomber

Melissa K Brown

Hugh R McMullin

This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.

Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor

Methods and implant devices for use in tissue repair. The implant devices include resorbable, swellable implant bodies, formed from a dehydrated crosslinked biocompatible polymer. The implant devices are capable of swelling after insertion into tissues to become anchored in place.

Devices for tissue repair and methods for preparation and use thereof

Disclosed herein are uniformly shaped swellable devices comprising polymeric materials, as well as apparatuses and processes for their manufacture. In one embodiment, the present invention relates to load bearing implant devices for use in tissue repair. The implants consist of a resorbable, swellable implant body which is formed from a dehydrated crosslinked biocompatible polymer. As such, the implants are capable of swelling after insertion to become anchored in place. The implants function to enhance the structural integrity of the hard tissue into which they are placed, and thereby improve the load bearing capacity of such tissues. The implants are particularly well suited for use in attaching a second (hard or soft) tissue to the first (hard) tissue into which the implant is inserted. They may also be used as a site for attachment of a surgical device such as a screw, rod or pin.

It has been discovered that it is possible to treat solutions of connective tissue material for the inactivation of prions in a manner such that connective tissue molecules are not adversely affected by the inactivation treatment. For example, solubilized atelopeptide collagen can be treated with sodium hydroxide for the inactivation of prions and other infectious agents without affecting the ability of the solubilized collagen to form stable fibers. In accordance with the present invention, a first method for the treatment of connective tissue materials such as collagen for the inactivation of prions and other infective agents, to obtain at least 5 logs of protection, comprises the following steps:

Prion inactivation in connective tissue materials

In accordance with the present invention, stabilized dispersions of collagen fibers that have been treated in order to inactivate infectious agents and methods of stabilizing such collagen fibers are provided.

Method of controlling structure stability of collagen fibers produced

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Sunnyvale, CA, United States of America

Vivek N Shenoy