Bpgbio, Inc.

University of Miami

Berg LLC

Vivek K Vishnudas

Niven Rajin Narain

Rangaprasad Sarangarajan

Sylvia Daunert

Viatcheslav R Akmaev

Sapna K Deo

Enxuan Jing

Stephane Gesta

Emre Dikici

Min Du

Tony Walshe

Anne R Diers

Pirouz Mohammad Daftarian

Joaquin Juan Jimenez

Methods for identifying a modulator of angiogenesis and methods for modulating angiogenesis in a mammalian subject are described herein. In some embodiments, the methods include obtaining data sets from a model for angiogenesis and generating a causal relationship network model based on the obtained data. In some embodiments, the methods include identifying, from the causal relationship network model, a causal relationship unique in angiogenesis, where a gene, lipid, protein, metabolite, transcript, or SNP associated with the unique causal relationship is identified as a modulator of angiogenesis.

Interrogatory cell-based assays and uses thereof

The invention provides methods and compositions for treatment of a subject with a glioma that has failed treatment with temozolomide (TMZ) comprising administration of a composition comprising a Coenzyme Q10 compound to the subject. The invention also provides a method of treating a cancer that exhibits increased Complex II activity in a subject comprising administration of a composition comprising a Coenzyme Q10 compound to the subject.

Methods of treatment of temozolomide-resistant glioma using coenzyme Q10

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Bedford, MA, United States of America

Vivek K Vishnudas