Dr. Lo. Zambeletti S.p.a.

Simes

Simes Societa Italiana Medicinali E Sintetici

Dr. L. Zambeletti Spa

Smithkline Beecham Farmaceutici

Siphar S.a.

Dr. Lo. Zambelletti Spa

Lo Zambeletti S.p.a.

Dr. Lo Zembeletti S.p.a.

Simes, Societa Italiana Medicinalle Sintetici

Vittorio Vecchietti

Giorgio Ferrari

Giuseppe Giardina

Antonio Giordani

Roberto Colle

Giulio Dondio

Massimo Signorini

Cesare Casagrande

Emilio Mussini

Silvano Ronzoni

Mario Bergamaschi

Robert Colle

Lorenzo Leurini

Gian B Gervasi

##STR1## Compounds of formula (I) in which, R is linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl or furan-2-yl alkyl; R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R.sub.3 is hydrogen, hydroxy or alkoxy; 'Het' is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R.sub.4 and R.sub.5, which may be the same or different, are each hydrogen alkyl, halogen, nitro; CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain.

Hydroisoquinoline derivatives

##STR1## Azacyclic derivatives of formula (I), in which R.sub.1 and R.sub.2 are each linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkenyl or alkynyl; R.sub.3 and R.sub.4 are identical, and each is a hydrogen or alkyl; and R.sub.5 is hydrogen or alkyl, and their use in medicine are disclosed.

1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists

N-acyl-substituted azacyclic compounds, processes for their preparaion,

N-acyl-substituted azacyclic compounds, processes for their preparation,

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4-12 cycloalkylalkyl groups or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom;

Substituted isoquinoline compounds, pharmaceutical composition and

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring;

Heterocyclic piperidinyl compounds having analgesic effect

A compound of formula (I): ##STR1## or a salt and/or solvate thereof, wherein R represents an acyl group containing a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic group;

2-aminoethylamine derivatives, compositions of the same and use of said

A compound, or a solvate or salt thereof, of formula I: ##STR1## in which: R.CO-- is an acyl group containing a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic group;

Heterocyclic ethylene diamine compounds and their pharmaceutical

A compound, or a solvate or salt thereof, of formula (I) ##STR1## in which: R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4-12 cycloalkylalkyl groups, or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom, provided that R.sub.1 and R.sub.2 are not simultaneously hydrogen;

Azacyclic compounds and their use as analgesic agents

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R.sub.1 R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4 -12 cycloalkylalkyl groups or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom;

Isoquinoline derivatives and their use as analgesics

Novel piperidine derivatives

A compound of formula (I): ##STR1## or a salt or solvate thereof in which R.CO is an acyl group in which R is of formula (II) ##STR2## in which R.sub.3 is Br, NO.sub.2 or CF.sub.3 ; and, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, is useful for treating pain.

Piperidine analgesics

A compound of formula 1, or a solvate or salt thereof: ##STR1## in which: RCO is an acyl group in which the group R comprises a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl groups or together form a C.sub.3-6 polymethylene or alkenylene group, is useful for treating pain.

Isoquinoline derivatives, analgesic compounds thereof and method of

A compound of formula (I): ##STR1## or a salt or solvate thereof in which R. CO is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, and p is 1, 2, 3 or 4, is useful for treating pain.

Cyclic carboxamide derivatives and their use as analgesics

A compound of formula I: ##STR1## or a solvate or salt thereof in which: R is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl groups or together form a C.sub.3-6 polymethylene or alkenylene group, is useful for treating pain in mammals.

Growing community of inventors

Milan, Italy

Vittorio Vecchietti