Fidia Farmaceutici S.p.a.

Anika Therapeutics S.r.l.

Fidia S.p.a.

Fidia Advanced Biopolymers S.r.l.

M.u.r.s.t. (italian Ministry for Universities and Scientific and

M.u.r.s.t. Italian Ministry for Universities and Scientific and Technological Research

Vittorio Crescenzi

Lanfranco Callegaro

Davide Bellini

Davide Renier

Anna Taglienti

Cristina Longinotti

Andrea Francescangeli

Francesco Della Valle

Devis Galesso

Stefania Panero

Di Meo Chiara

Gianluca Abbati

Filippo Biviano

Chiara Di Meo

New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier to prevent post-surgical adhesions in abdominal, pelvic and, above all, spine surgery.

Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions

Crosslinked derivatives of polycarboxylated polysaccharides are described, wherein at least one of the polysaccharide chains consists of hyaluronic acid or a derivative thereof, crosslinked by means of reactions of the 'click chemistry' type and their use in the field of viscosupplementation, plastic surgery, oncologic and reconstructive surgery and also as matrices for controlled release systems of biologically and/or pharmacologically active molecules and/or macromolecules.

Hyaluronic acid derivatives obtained via 'click chemistry' crosslinking

The present invention relates to percarboxylated polysaccharide selected from the group consisting of gellan, carboxymethylcellulose, pectic acid, pectin and hyaluronic acid derivatives; the process for their preparation and their use in the pharmaceutical, biomedical, surgical and healthcare fields.

Percarboxylated polysaccharides, and a process for their preparation

The present invention concerns the preparation of composite biomaterials constituted by hyaluronic acid and the derivatives thereof in combination with polymers that have electrically conductive properties. In particular, the methods of preparing biomedical devices formed by a two- or three-dimensional polysaccharide matrix and by an electrically conductive membrane. The matrix is constituted by hyaluronic acid derivatives in the form of membranes, woven fabrics, nonwoven felts, meshes, gauzes, guide channels or sponges, while the electrically conductive membrane is constituted by a film of polypyrrole (polymer conductor) in combination with hyaluronic acid or a derivative thereof (doping agent).

Electrically conductive polymeric biomaterials, the process for their preparation and the use thereof in the biomedical and healthcare field

The present invention describes a new class of cross-linked derivatives of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I) hereinafter depicted and a process for the preparation of said cross-linked derivatives, comprising a multicomponent condensation reaction involving the carboxy groups and the amino groups originating from a partial N-deacetylation of hyaluronic acid or derivatives, together with an aldeyde and an isocyanide. The derivatives thus obtained can be used, alone or in association with biologically and/or pharmacologically active substances, for the preparation of pharmaceutical compositions, biomaterials, surgical and healthcare articles, slow release systems and for the coating of biomedical objects.

Cross-linked derivatives of hyaluronic acid

The present invention is drawn to inner esters of gellan, wherein the carboxy groups are esterified with hydroxy groups from either the same or different molecules of gellan. The present invention is further drawn to methods of using the present inner esters of gellan in the fields of cosmetics, pharmaceuticals and in sanitary and surgical articles. The present invention is further drawn to products made from inner esters of gellan and to be used in the indicated fields.

Auto-cross-linked gellan gum

Pectic acid and pectinic acid may be totally or partially esterified with aliphatic, arylaliphatic, cycloaliphatic or heterocyclic alcohols. When the acid is only partially esterified, the remaining free carboxyl groups may be salified with inorganic or organic bases. The esters may be used in the pharmaceutical, biomedical, alimentary and cosmetic fields. The esters may be prepared from a quaternary ammonium salt of pectic acid or pectinic acid and an esterifying agent such as a halogenide.

Esters of pectic and pectinic acid

The present invention is directed to total and partial esters of gellan in which the esterifying alcohol component is derived from aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohols, and salts of said partial esters with inorganic or organic bases, and compositions containing the same.

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Rome, Italy

Vittorio Crescenzi