Chiesi Farmaceutici S.p.a.

Vittorino Servadio

Paolo Chiesi

Paolo Ventura

Gabriele Amari

Maurizio Del Canale

Renato De Fanti

Maurizio Delcanale

Roberto Pighi

Fausto Pivetti

Eleonora Ghidini

Flavio Villani

Roberta Razzetti

Stefano Bongrani

Bluetta Salsi

Claudio Pietra

Walter Recchia

Roberta Rassetti

A process for the preparation of compounds of formula (I),

Process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity

A process, and variations thereof, for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalene derivatives of formula (I), wherein R.sub.1, R.sub.2, R.sub.3 can independently be hydrogen or lower alkyl.

Process for the preparation of

Process for the preparation of 5-6-dihydroxy-2-amino-1, 2, 3,

Process for the purification of natural pulmonary surfactant material

Geneserine derivatives processes as cholinesterase inhibitors

2-Propyl-2-pentanoic acid (valproic acid) esters and (E)-2-propyl-2-pentenoic acid [(E)-2-valproenoic acid] esters surprisingly proved to have valuable properties, in that they show anticonvulsive and antiepileptic activities comparable with those of valproic acid, as well as an improved bioavailability and a markedly reduced toxicity.

Valproic and (E)-2-valproenoic acid derivatives, and pharmaceutical

5,6-Dimethoxy-2-[2-(4-hydroxyphenyl)-2-hydroxy-2-methylethyl]amino- 1,2,3,4-tetrahydronaphthalene has inotropic and vasodilating activities and therefore can be used in the treatment of cardiocirculatory failure. The compound can be in the form of a single stereoisomer or as a mixture of two or more stereoisomers.

2-amino-1,2,3,4-tetrahydronaphthalene derivatives with cardiovascular

Thiomethyl and sulfinylmethyl derivatives having gastric acid

Imidazo[4,5-c] pyridine compounds and physiologically acceptable salts thereof having antiulcer and gastric acid antisecretory activities and pharmaceutical compositions containing them.

Imidazole [4,5-c] pyridine derivatives having gastric acid antisecretory

Isosorbide 2- and 5-mononitrate esters with aliphatic, aryl, or cynnamic acids or diacids, or with alkylcarbonyloxy substituents optionally containing an isosorbide 2- or 5-mononitrate group, are useful in human therapy.

1,4:3,6-dianhydrosorbitol 2-mononitrate and 5-mononitrate esters and

Compounds of formula I ##STR1## wherein A represents: a saturated or unsaturated acyclic residue;

Thiazolidine derivatives, process for their preparation and

Compounds of formula I ##STR1## wherein A represents: a saturated cyclic or heterocyclic aromatic or heteroaromatic residue;

Homocysteine thiolactone derivatives, process for the preparation

New inclusion compounds of 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dio xide with .alpha., .beta. or .gamma. cyclodextrins, obtained by reaction of said cyclodextrins and said 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxyamide-1,1-dio xide in aqueous or water/organic solutions are described. The ratio between 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-1,1-dioxide and the cyclodextrins is comprised between 1:10 and 1:1; preferably, it is about 1:2.5. The compounds of the invention possess high antiinflammatory and analgesic activities, together with a considerably reduced gastrolesive action.

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Parma, Italy

Vittorino Servadio