Farmitalia Carlo Erba S.p.a.

Farmitalia Carlo Erba S.r.l.

Vittoria Villa

Enrico Di Salle

Paolo Lombardi

Franco Faustini

Carmelo Gandolfi

Roberto D'Alessio

Roberto d'Alessio

The invention relates to new 17-hydroxy androsta-1,4-diene-3-one derivatives of the following formula ##STR1## wherein each of R and R.sub.3, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl;

17-Substituted androsta-1,4-dien-3-one derivatives

The invention relates to 6-substituted 10.beta.-alkynylestrene derivatives wherein the 6 substituent is amino, azido, halogen or an alkylidene group and to corresponding 6,7-dihalo analogs. The invention provides also a process for the preparation of the above compounds and pharmaceutical compositions containing same. The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.

6-Alkylidene 10 .beta.-alkynylestrene derivatives and pharmaceutical

The invention relates to 6-substituted androsta-1,4-diene-3,17-dione derivatives wherein the 6 substituent is an azido, amino or substituted amino group. The invention provides also a process for preparing the said compounds and pharmaceutical compositions containing same. The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors.

Steroidic aromatase inhibitors

The invention discloses 4-substituted androstendione derivatives of the following formula (I) ##STR1## wherein R is amino or substituted amino or azido,

4-amino androstendione derivatives and process for their preparation

Esters of 13,14-didehydro prostaglandins have been prepared.

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Milan, Italy

Vittoria Villa