Aventis Pharma Deutschland, Gmbh

Vitthal G Gund

Bansi Lal

Ashok Kumar Gangopadhyay

A cyclohexapeptide compound of general formula (I), wherein Ris C&#x2013;Calkyl; C&#x2013;Calkenyl; C&#x2013;Calkoxyphenyl; an aryl group selected from: phenyl, biphenyl, terphenyl and naphthyl; C&#x2013;Calkylphenyl, C&#x2013;Calkenylphenyl, C&#x2013;Calkoxyphenyl; linoleoyl; palmitoyl; 12-methylmyristoyl; 10,12-dimethylmyristoyl; or &#x2014;COCH(p)OCH, Rand Rare independently &#x2014;OH; &#x2014;CN; &#x2014;CHNH; &#x2014;N; aryl; substituted aryl; heterocyclyl and substituted heterocyclic with 1&#x2013;3 of the same or different heteroatoms; aminoalkylamino; mono or di-substituted linear or cyclic aminoalkylamino; &#x2014;OR, wherein, R is C&#x2013;Calkyl; substituted alkyl of the type &#x2014;(CH)&#x2014;X, where n is 1&#x2013;5 and X is Cl, Br, I, COOY, CN, NHor a heterocyclic and where Y is C&#x2013;Clinear or branched alkyl; C&#x2013;C-alkenyl; aryl; fused aryl; substituted aryl; a heterocyclic containing 1&#x2013;3 heteroatoms; mono or di-substituted aminoalkyl; or a hydroxy protecting group; and Rmay additionally be imidazolyl; Rand Rare independently &#x2014;H or &#x2014;OH; Ris &#x2014;H or &#x2014;CH, Ris &#x2014;H, &#x2014;CHor &#x2014;CHCONH. Ris &#x2014;H, &#x2014;CHor &#x2014;OH. Rand Rare independently &#x2014;H or &#x2014;CH-Sec.amine in which the sec.amine is attached to &#x2014;CHthrough its N linkage; and its pharmaceutically acceptable salts. The compounds are useful as antifungal agents.

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Sherbrooke, Canada

Vitthal G Gund